The BioFlo 610 is the linchpin of fermentation scale-up, simultaneously providing manufacturing-scale features with pilot-scale flexibility. It helps clients quickly and cost-effectively advance from “proof-of-concept” to “proof-of-scale.”
Controls: Temperature, pH, dissolved oxygen, and pressure
Additions: Up to 4
Use Case
Pilot-scale validation & sample generation
Growth Curve Bio uses the BioFlo 610 to transition processes from the bench to a manufacturing-relevant environment. This system allows us to validate performance under pressure and mass transfer dynamics that are more similar to those seen at full production scale. The BioFlo 610 produces sufficient volumes of fermentation broth for representative downstream processing trials, and often generates enough sample material for clients to test the product in its intended application.
Why BioFlo 610?
Manufacturing-ready vessel design: Three Rushton impellers, four removable baffles, and a 2:1 aspect ratio mirror the conditions in large-scale production vessels
Precise control: Built-in load cells provide accurate mass data, and 4 peristaltic pumps enable complex, highly-controlled feeding and inducing strategies
Operational parameters: Setpoints for temperature, pH, and dissolved oxygen, along with dissolved oxygen cascade (agitation, aeration, pressure, supplemental gas)
Key Outputs
Precise data: High-resolution logs of temperature, pH, dissolved oxygen (and components of the dissolved oxygen cascade)
Analytical material: Fermentation broth for offline analytics (at GCB, client site, or third-party lab)
DSP material: Fermentation broth for pilot-scale downstream processing
Scalable protocol: Recipes (including media sterilization) and control logic that are ready for demo and/or manufacturing scale vessels
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